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News & Press: Clinical News

Lipoprotein(a) as a Determinant of Coronary Heart Disease in Young Women: A Stronger Risk Factor

Friday, September 13, 2013   (0 Comments)
Posted by: Sandra Tremulis
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Lipoprotein(a) as a Determinant of Coronary Heart Disease in Young Women: A Stronger Risk Factor Than Diabetes?


Finally, the increased risk of coronary artery disease in postmenopausal women appears to be mediated in part by a 25% increase in the serum lipoprotein(a) levels that occurs after menopause.12 A decrease in lipoprotein(a) levels of similar magnitude has been reported as a result of estrogen replacement therapy with or without progesterone.12 More importantly, estrogen replacement therapy produces a greater reduction of lipoprotein(a) in those with elevated levels. For example, estrogen replacement therapy results in a 50% reduction in lipoprotein(a) levels in subjects with baseline levels >20 mg/dL compared with a 10% reduction in those with <20 mg/dL.13 The beneficial effects of estrogen replacement therapy on other lipoproteins are well known. Evidence has accumulated regarding the antiatherogenic and cardioprotective effects of estrogen replacement therapy, which include a 50% reduction in the risk of coronary artery disease in humans and a 72% reduction in coronary plaque size in monkeys.14 Considering these benefits and the low cost and low side effect profile, estrogen replacement therapy appears to be the right thing to do in women with coronary artery disease and elevated lipoprotein(a), even though the benefits of lowering the lipoprotein(a) levels have not yet been proven.

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