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Initial Results Lp(a) Therapies Under Development

Thursday, November 10, 2016   (0 Comments)
Posted by: Sandra Tremulis
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November 10, 2016 - Lipoprotein(a) Foundation Highlights AHA Research Presenting Initial Results of Therapies Under Development to Reduce Lp(a)


Study Published in AHA Journal Demonstrates that Reducing High Lp(a) in those at Highest Risk could have a Significant Impact on the Burden of Cardiovascular Disease

Lancet Reviews Clinical Implications of the Findings from Trials of Two ASOs Targeting Lp(a)


NEW ORLEANS--()--The Lipoprotein(a) Foundation is highlighting a number of studies presenting initial results of therapies under development to reduce Lipoprotein(a), also known as Lp(a), at the upcoming American Heart Association’s (AHA) Scientific Sessions 2016, November 12-16, 2016 in New Orleans. Members of The Lipoprotein(a) Foundation’s Scientific Advisory Board were involved with many of the studies being presented, as well as recently published studies that bolster the growing body of research that demonstrates the impact of elevated Lp(a) and its significance as an independent, genetic risk factor for early cardiovascular disease.

The study "Estimating the Population Impact of Lp(a) Lowering on the Incidence of Myocardial Infarction and Aortic Stenosis," was recently published in the American Heart Association journal, Arteriosclerosis, Thrombosis, and Vascular Biology. With potent Lp(a)-lowering therapies on the horizon, researchers sought to estimate the potential population impact of Lp(a) lowering that may be achieved by these therapies in primary prevention. Results showed that reducing high Lp(a) could potentially prevent up to 1 in 14 cases of myocardial infarction and 1 in 7 cases of aortic valve stenosis. The authors conclude that reducing high Lp(a) in those at highest risk could have a significant impact on the burden of cardiovascular disease.

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